Pair Name	Sanguinarium, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	AREG	hsa374
	Down-regulation	Expression	EGFR	hsa1956
	Down-regulation	Phosphorylation	JUN	hsa3725
	Down-regulation	Phosphorylation	MAPK8	hsa5599
	Down-regulation	Expression	MKI67	hsa4288
In Vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
Result	Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM.

Pair Name	Sanguinarium, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	A2780/CP70	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0135
Result	These findings suggest that sanguinarine could reverse cisplatin resistance in A2780/R cells through GSH reduction,sanguinarine can be used as one of the potent adjuvants for ovarian cancer chemotherapy.